Clin Res Cardiol 100, Suppl 1, April 2011

P1343 - Assessment of right ventricular function and dimension: comparison of full volume 3D Echocardiography and Cardiovascular Magnetic Resonance Imaging before and after endurance running
 
S. Schattke1, M. Wagner2, R. Hättasch1, S. Schroeckh3, T. Durmus2, I. Schimke1, W. Sanad1, G. Baumann1, A. C. Borges4, F. Knebel1
 
1CC13, Med. Klinik m. S. Kardiologie und Angiologie, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin; 2Institut für Radiologie, Charité Campus Mitte, Berlin; 3Klinik für Dermatologie, Venerologie und Allergologie, Berlin; 4Klinik für Innere Medizin I - Kardiologie, HELIOS Klinikum Emil von Behring GmbH, Berlin;
 
Purpose: In recent studies it has been shown that after prolonged physical exercise right ventricular (RV) ejection fraction drops while RV volume increases. These studies have been performed using either 2D Echocardiography or Cardiovascular Magnetic Resonance Imaging (CMR) alone. Our study compares new 3D Echocardiography to CMR, both performed immediately after exercise. 
Methods: 21 experienced non-elite male marathon runners (mean age 45,7 ±14,8, range 22-69 years) were examined by echo (Siemens ACUSON SC2000, matrix transducer 4Z1c), CMR (Siemens Sonata1.5T) and blood tests before and immediately after each ran 30km. In order to exclude effects of acute volume changes, the runners were not allowed to re-hydrate after the race. The order of either echo or CMR examination was randomized. The full volume echocardiography volume rates were 11-20/s.
Results: 3D-Echo and CMR data acquisition of the RV was feasible in all subjects. The decrease of mean body weight from 75,5kg ±7,9kg to 73,2kg ±8kg (p<0.001) and the significant increase of hematocrit (0,43 to 0,44, p=0,018) indicate dehydration.
CMR showed no difference in the ejection fraction before and after the run (55,7 ±6,4 vs. 54,0 ± 8,3%, p=0,095), while RV end-diastolic and end-systolic volume and stroke volume decreased (RVEDV: 216,0 ±31,2ml vs. 190,5 ±30,9ml, p=0,001; RVESV: 96,3 ±23,6ml vs.  86,9  ±19, 0ml, p=0,009; RVSV  119,6  ±17,1ml, vs. 103,6ml  ±22,5ml, p=0,001).
3D echo showed no difference in the ejection fraction before and after the race (53.0± 3.3 vs. 51.8 ± 4,0 %,  p=0,23). However 3D Echo could neither confirm the reduction of RVEDV (156,1 ± 44,4 ml vs. 144,6 ± 36,4 ml, p=0,149), RVESV (73,0 ± 19,8 ml vs. 70,4 ± 20,2 ml, p=0,357) nor RVSV (83,1 ± 25,4 vs. 74,2 ± 18,3 ml, p=0,14) that was measured in CMR.
The increase in leukocytes (6,35/nl to 13,11/nl, p< 0,001),and IL6 (1,01ng/l to 30,02ng/l, p< 0,001) reflects an inflammatory response. There is an elevation of the cardiac biomarkers high sensitive TnT (2,52ng/l to 14,07ng/l, p< 0,001), NT-proBNP (50,95ng/l to 102,05ng/l, p< 0,001)
Conclusion: Both methods indicate a preserved RV systolic function after endurance exercise. The dimensions of the RV are larger in CMR than in 3D echo.  The CMR indicated a reduction of RV volumes, whereas this was not confirmed by echo.  We conclude that endurance exercise does not induce acute RV dysfunction.
 
Clin Res Cardiol 100, Suppl 1, April 2011
Zitierung mit Vortrags- oder Posternummer s.o.
DOI 10.1007/s00392-011-1100-y

http://www.abstractserver.de/dgk2011/ft/abstracts/P1343.htm