Clin Res Cardiol 100, Suppl 1, April 2011

P391 - Diastolic heart failure in a six-year follow-up study in patients after acute myocarditis
F. Escher1, D. Westermann1, R. Gaub1, C.-T. Bock2, N. Al-Saadi1, U. Kühl1, H.-P. Schultheiss1, C. Tschöpe1
1Med. Klinik II, Klinik für Kardiologie und Pulmologie, Charité - Universitätsmedizin Berlin, Campus Benj. Franklin, Berlin; 2Molekulare Epidemiologie viraler Erreger, Robert-Koch-Institut, Berlin;
Background: The aim of this study was to analyse the long-term prognosis of patients with acute myocarditis (AMC), who had been discharged from the hospital while having normal left ventricular (LV) function.
Methods and Results: We prospectively studied 50 patients with acute myocarditis, which underwent endomyocardial biopsies (EMBs). We examined their clinical condition in a mean follow-up period of 72 (54-78) months, including tissue Doppler imaging (TDI). 4% (2/50) died, and 6% (3/50) developed dilated cardiomyopathy. 45/50 (90%) showed a normal or improvement of LV function over time. In the course of the follow-up, 49% (22/45) suffered from heart failure symptoms despite normal ejection fraction (HFNEF). This was associated with an abnormal E/A ratio, an impaired deceleration time of early mitral flow velocity (DT) and isovolumic relaxation time (IVRT) and a pathological increase in the LV filling index E/E’, in contrast to patients without heart failure symptoms (E/E’septal 10.9 (9.3-13.8) vs. 6.8 (6.4-9.1); P=0.001). The plasma NT-proBNP levels were increased 3-fold in patients with HFNEF (19.9 (10.6-24.1) vs. 7.3 (4.2-11.9) pmol/L; P=0.006).
Conclusions: We assume that the evidence of AMC is associated not only with the risk of developing LV dilatation but also with an increased risk of symptomatic diastolic dysfunction after later years.
Clin Res Cardiol 100, Suppl 1, April 2011
Zitierung mit Vortrags- oder Posternummer s.o.
DOI 10.1007/s00392-011-1100-y