Clin Res Cardiol 100, Suppl 1, April 2011

P396 - Predictive Value of HMGB1 in Patients with Congestive Heart Failure
D. Laohachewin1, H. C. Volz1, D. Schellberg2, M. Nelles1, C. Zugck1, H. A. Katus1, M. Andrassy1
1Innere Med. III, Kardiologie, Angiologie u. Pneumologie, Universitätsklinikum Heidelberg, Heidelberg; 2Innere Med. II, Psychosomatische u. Allgemeine Klinische Medizin, Universitätsklinikum Heidelberg, Heidelberg;
Background: High Mobility Group Box 1 (HMGB1) has been established as an important mediator of myocardial inflammation and progression of heart failure in experimental models. Therefore our study investigated the HMGB1 levels in patients with heart failure and its ability to provide independent prognostic information.
Methods and Results: We conducted our analysis of HMGB1 plasma concentration in 104 patients with systolic heart failure and correlated the results with severity of disease and prognosis (mean follow-up time 2 years). HMGB1 in patients suffering from heart failure was significantly elevated compared to healthy controls regardless of diagnosis (median 3.12 vs. 10.69 ng/ml, Interquartile range 0.63 vs. 4.97 ng/ml p<0.000). HMGB1 levels were significantly higher in moderate to severe heart failure compared to no or mild symptoms as well (median 4.73 ng/ml, Interquartile range 3.54 for NYHA classes I/II compared to 12.88 ng/ml, Interquartile range 4.89 for NYHA classes III/IV). In survival models for the combined endpoint of death and heart transplantation, HMGB1 proved to be an independent predictor at a cut-off value of 5.1 ng/ml obtained by ROC-analysis (hazard ratio 3.8, 95% CI 1.7-8.8, p=0.001). In a multivariate cox regression model including NTproBNP, serum creatinine, age, NHYA classification and age, HMGB1 remained an independent predictor of the combined endpoint (hazard ratio of 3.3, 95% CI 1.3-8.1, p=0.009).
Conclusion: Our findings demonstrate that HMGB1 plasma concentration correlates with disease severity and is an independent predictor of the combined endpoint death and heart transplantation in heart failure patients.
Clin Res Cardiol 100, Suppl 1, April 2011
Zitierung mit Vortrags- oder Posternummer s.o.
DOI 10.1007/s00392-011-1100-y