Clin Res Cardiol 100, Suppl 1, April 2011

P400 - Plasma vitamin C predicts incident heart failure in men and women in EPIC-Norfolk prospective study
R. Pfister1, N. Wareham2, K.-T. Khaw3
1Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Köln; 2Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, Großbritannien; 3Department of Public Health and Primary Care, Institute of Public Health, Cambridge, Großbritannien;
Background: Fruit and vegetable intake has been associated with lower risk for cardiovascular risk factors and disease, but data on heart failure are sparse and inconsistent. The association of plasma vitamin C, a biomarker reflecting fruit and vegetable intake, with heart failure has not been studied.
Methods: We examined the prospective association of plasma vitamin C concentrations and incident fatal and non-fatal heart failure events in apparently healthy 9,187 men and 11,112 women aged 39-79 participating in the “European Prospective Investigation into Cancer and Nutrition” (EPIC) study in Norfolk.
Results: During a mean follow-up of 12.8 years 1,258 incident cases of heart failure occurred. The risk of heart failure decreased with increasing plasma vitamin C; the hazard ratios comparing each quartile with the lowest were 0.76 (95% CI 0.65-0.88), 0.70 (95% CI 0.60-0.81) and 0.62 (95% CI 0.53-0.74) in age- and sex-adjusted analysis (p for trend <0.0001). Every 20 µmol/l increase in plasma vitamin C concentration (1 SD) was associated with a 9% relative reduction in risk of heart failure after adjustment for age, sex, smoking, alcohol consumption, physical activity, occupational social class, educational level, systolic blood pressure, diabetes, cholesterol concentration and body-mass index, with similar result if adjusting for interim coronary heart disease.
Conclusion: Plasma vitamin C, a biomarker reflecting fruit and vegetable intake, was inversely associated with the risk of heart failure in this apparently healthy population.
Clin Res Cardiol 100, Suppl 1, April 2011
Zitierung mit Vortrags- oder Posternummer s.o.
DOI 10.1007/s00392-011-1100-y